The present study investigated the hypoglycemic and antihyperglycemic potential of combination of sitagliptin and ursolic acid in normal fasted rats. In addition, the acute oral toxicity study on test drug combinations was conducted. The combination of sitagliptin and ursolic acid were studied at the ratio of 70:30, 50:50 and 30:70 treatment group. The oral administration of sitagliptin to non-diabetic rats produces mild hypoglycemia (p<0.01) whereas combinations of sitagliptin and ursolic acid did not show any significant decrease in the blood glucose below normal level when compared with normal control group. In oral glucose tolerance test, all groups treated with combination of sitagliptin and ursolic acid showed significant decrease in elevated glucose level (p<0.01) towards the normal as compared to control group. These results suggest that test drug combination possesses beneficial antihyperglycemic activity in controlling the elevated glucose level in non diabetic rats.
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